Project Overview

Synthesis of Metabolically Stable Tn Antigen Mimics with Conformational Integrity

Faculty Sponsor

Ernie Nolen (enolen@colgate.edu)

Department(s)

Chemistry

Abstract

Tn antigen is a carbohydrate bound to serine or threonine of a membrane protein, and is found displayed exclusively on the surface of tumor cells. While the immune system recognizes this feature as unique, it generally does not mount a significant defensive attack with respect to Tn antigen.  To aid in the understanding of immunorecognition and in the development of potential cancer vaccines, we have designed and are attempting to construct conformational mimics of Tn antigen that have an extended half-life, and therefore expected to produce a more robust immune response.  The actual lab work involves organic molecule synthesis and purification of these new materials, as well as characterization of these structures by NMR and mass spectrometry.

Student Qualifications

Students should have completed CHEM 263-264 courses for serious consideration.

Number of Student Researchers

2 students

Project Length

8 weeks


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If you have questions, please contact Karyn Belanger (kgbelanger@colgate.edu).