Project Overview
Sensory regeneration from latent progenitors
Department(s)
Biology
Neuroscience
Abstract
Loss of sensory cells in the human eye or ear results in permanent loss of function in those systems, as we have no ways to repair that damage. In contast, in the zebrafish, non-sensory progenitor cells have the capacity to regenerate sensory cells that get fully integrated into the system and can restore function following damage. We are examining the signals that are used to coordinate this regenerative response in fish, from the cues that initiate the proliferation to the organization of the differentiated progeny. Experiments will utilize larval fish and rely heavily on microscopy, genetics and pharmacology to manipulate key components of the processes under investigation and to analyze the results.
Student Qualifications
Biol 182 or Neur 170 strongly preferred but not required
Project Length
10 weeks
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