Project Overview

Why don’t frogs get fevers?

Faculty Sponsor

Anzela Niraula (aniraula@colgate.edu)

Department(s)

Neuroscience
Psychological and Brain Sciences

Abstract

Thermoregulation, the ability to alter body temperature, is necessary for mounting an immune response against pathogens. An example of thermoregulation during an immune challenge is fever in mammals. Unlike in mammals, the capacity for thermoregulation is diminished in amphibians causing these animals to migrate to warmer locations in the event of an infection. This project investigates the neuronal circuits that govern immune response to infections and the role of the brain-fat axis in temperature regulation in Xenopus laevis, the African clawed frog. Students will utilize fine dissection skills, pharmacological manipulations, behavioral testing, biochemistry, and microscopy to pursue the project goals.

Student Qualifications

- Interest in the topic, motivation, dexterity, and strong work ethic needed
- No prior research experience required

Number of Student Researchers

2 students

Project Length

8 (starting June 30) weeks

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If you have questions, please contact Karyn Belanger (kgbelanger@colgate.edu).