Project Overview
Why frogs don’t get fevers
Department(s)
Neuroscience
Psychological and Brain Sciences
Abstract
Thermoregulation, the ability to alter body temperature, is necessary for mounting an immune response against pathogens. An example of thermoregulation during an immune challenge is fever in mammals. Unlike in mammals, the capacity for thermoregulation is diminished in amphibians causing these animals to migrate to warmer locations in the event of an infection. This project investigates the neuronal circuits that regulate immune response and the role of the brain-adipose tissue axis in thermoregulation in Xenopus laevis, the African clawed frog. Students will utilize fine dissection skills, pharmacological manipulations, behavioral testing, biochemistry, and microscopy to pursue the project goals.
Student Qualifications
- Interest in the topic, motivation, dexterity, and strong work ethic needed
- No prior research experience required
Number of Student Researchers
2 students
Project Length
8 weeks
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