Project Overview

Mechanism and Functional Consequences of Innate Immune Responses to Reovirus Infection

Faculty Sponsor

Geoff Holm (gholm@colgate.edu)

Department(s)

Biology

Abstract

The objective of this project is to understand the regulation of IRF-3 following reovirus infection. IRF-3 is crucial for cell fate decisions, including the induction of an antiviral response or the initiation of programmed cell death. The work will involve using pharmacologic inhibitors to block HDAC6 activity following infection, and determining their effect on transcription of IRF-3-dependent genes, via quantitative PCR, luciferase reporter activities, and chromatin immunoprecipitation.

Student Qualifications

Not sure if this needs to be shared for all students to access, especially since I already have 2 students in mind for the positions...

Number of Student Researchers

2 students

Project Length

8 weeks


Applications open on 01/15/2017 and close on 02/07/2017


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If you have questions, please contact Karyn Belanger (kgbelanger@colgate.edu).