Project Overview
Using an expanded genetic code to study redox biology
Department(s)
Chemistry
Abstract
This project utilizes chemical tools in order to study how biological systems regulate redox stress. We can engineer cells to build proteins using an expanded set of amino acids, beyond those that are naturally available to the cells. We specifically use this approach (which is called
genetic code expansion) to produce redox-active proteins that are challenging or impossible to produce with traditional techniques. Once we have expressed these proteins, we can then study how they function and what role they play in biological redox regulation. The lab will use genetic code expansion to study two different biological systems: 1) human selenoproteins, and 2) bacterial proteins that have been modified through acetylation.
Student Qualifications
Chem 102 or Chem 111 required
Number of Student Researchers
2 students
Project Length
8 weeks
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