Hydroxamic acids (HAs), represented with a general formula RCONHOH, are a unique class of compounds with metal- chelating properties which plays a vital role in drug discovery. This class of compounds possesses a broad spectrum of biological activities. They are selective inhibitors of numerous enzymes, such as carbonic anhydrases (CAs), matrix metalloproteinases, (MMPs) and histone deacetylases (HDACs). Hydroxamic acid functional moiety is not only a strong metal binder but also possess multiple sites for H-bonding with enzymes. These unique properties of HAs are well utilized in the pharmaceutical industry. Despite numerous hydroxamic acid drug candidates have been well studied, thiohydroxamic acid analogs yet to be explored. Our lab will design and synthesize novel thiobenzohydroxomate analogs as HDAC6 selective inhibitors, and study their structure-activity relationship. Our lab will collaborate with the biology department to investigate the biological activity of our compounds.
No prior experience in chemical synthesis is required.