The goal of research in the Holm lab is to elucidate mechanisms by which cells detect and respond to infection by mammalian orthoreovirus (reovirus), and by which reovirus strains antagonize these responses. Ongoing projects in the lab aim to: i) understand the regulation of key cellular antiviral transcription factor IRF-3 as it navigates cell fate decisions that lead to either the induction of an antiviral state or programmed cell death; ii) identify and characterize cellular innate immune proteins (interferon stimulated genes) that restrict reovirus replication; and iii) understand how reovirus infection alters cellular metabolic pathways. Students will conduct experiments to answer these questions, with the aim of accumulating data for peer-reviewed publication and/or presentation at a research conference.
Minimum experience: Completion of Biol182, with a declared (or anticipated declaration) of a Biology or Molecular Biology major. Desired, but not required, qualifications include completion of a 200-level Biology course and/or a 300-level elective.